In silico analysis of formononetin compound as a breast anti Cancer

Suryani, Yani and Taupiqurrahman, Opik and Siti, R. and Kinasih, Ida and Paujiah, Epa In silico analysis of formononetin compound as a breast anti Cancer. IOP Conference Series: Earth and Environmental Science. ISSN doi :10.1088/1755-1315/175/1/012145

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Abstract

For long the relationship between estrogen and cancer has been proved. Formononetin is a phytoestrogen which has been reported to have anticancer effects. Phytoestrogens have the same structure and properties as human estrogen and can interact with ER-α without inducing any cell proliferation. While anticancer properties of Formononetin in prevention of other cancers like prostate and carcinoma colon have been studied, its effects on breast cancer remain unknown. The aim of the present study is to analyse the formononetin compound as a competitor of estrogen in terms of the bond quality with ER-α. The method used in this study was in silico or computation by molecular docking method using PvRx software. The data was also analysed using Discovery Studio software. The results showed that the formononetin compounds have a value of free energy equal to -7.3 kcal/mol, lower than 17-β-Estradiol (natural estrogen) that is -6.4 kcal/mol, but higher than 3 alkylnaphthalene (estrogen synthetic) that is -11.2 kcal/mol. Based on the results, formononetin has a great potential as an estrogen competitor because it has a value of free energy that is lower than the natural estrogen.

Item Type: Article
Uncontrolled Keywords: Breast Cancer; Estrogen; Formononetin; In Silico Modeling
Subjects: Biology
Biology > Education, Research, Related Topics of Biology
Divisions: Fakultas Sains dan Teknologi > Program Studi Biologi
Depositing User: Yani Suryani
Date Deposited: 31 May 2020 02:51
Last Modified: 31 May 2020 02:51
URI: http://digilib.uinsgd.ac.id/id/eprint/31047

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